Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

Irina Shcherbakova; Guangfei Huang; Otto J Geoffroy; Satheesh K Nair; Krzysztof Swierczek; Manuel F Balandrin; John Fox; William L Heaton; Rebecca L Conklin

doi:10.1016/j.bmcl.2005.03.054

Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40. doi: 10.1016/j.bmcl.2005.03.054.

Authors

Irina Shcherbakova¹, Guangfei Huang, Otto J Geoffroy, Satheesh K Nair, Krzysztof Swierczek, Manuel F Balandrin, John Fox, William L Heaton, Rebecca L Conklin

Affiliation

¹ Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. ishcherbakova@npsp.com

PMID: 15863312
DOI: 10.1016/j.bmcl.2005.03.054

Abstract

Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.

MeSH terms

Pyrimidinones / chemical synthesis*
Pyrimidinones / chemistry
Pyrimidinones / pharmacology*
Receptors, Calcium-Sensing / drug effects*
Structure-Activity Relationship

Substances

Pyrimidinones
Receptors, Calcium-Sensing